Increased Mast Cell Counts and Degranulation in Microscopic Colitis

RIII-dependent Mast Cell Degranulation and Anaphylaxis

In mouse mast cells, both Fc e RI and Fc g RIII are abg 2 tetrameric complexes in which different a chains confer IgE or IgG ligand recognition while the signaling FcR b and g chains are identical. We used primarily noninvasive techniques (changes in body temperature, dye extravasation) to assess systemic anaphylactic responses in nonanesthetized wild-type, Fc e RI a chain 2 / 2 and FcR g chain...

Anxiety and depression are associated with increased counts and degranulation of duodenal mast cells in functional dyspepsia.

BACKGROUND Patients with functional dyspepsia (FD) have increased risks for psychological dysfunction than healthy peoples. This study aimed to explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of FD. MATERIAL AND METHODS We prospectively included 48 FD patients and 21 age- and sex-match healthy volunteers. There were 23 patients with postprandial distress ...

Mechanism of Peptide-induced Mast Cell Degranulation

Substance P and other polycationic peptides are thought to stimulate mast cell degranulation via direct activation of G proteins. We investigated the ability of extracellularly applied substance P to translocate into mast cells and the ability of intracellularly applied substance P to stimulate degranulation. In addition, we studied by reverse transcription--PCR whether substance P-specific rec...

Inosine Binding Stimulates Mast Cell Degranulation

We investigated the mechanism by which inosine, a metabolite of adenosine that accumulates to . 1 mM levels in ischemic tissues, triggers mast cell degranulation. Inosine was found to do the following: ( a ) compete for [ 125 I] N 6 -aminobenzyladenosine binding to recombinant rat A 3 adenosine receptors (A 3 AR) with an IC 50 of 25 6 6 m M; ( b ) not bind to A 1 or A 2A ARs; ( c ) bind to newl...

Degranulation Age-Induced Reprogramming of Mast Cell