Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis
نویسندگان
چکیده
منابع مشابه
Protein carbonylation in human diseases.
Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease, chronic renal failure, diabetes and sepsis...
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Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers in the world, with limited options for treatment unless timely diagnosed. Chronic hepatitis C virus (HCV) infection and persistent heavy alcohol consumption are independent risk factors for HCC development, which may induce a specific protein expression pattern different from those caused separately. The aim of the stud...
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Abstrad We undertook a retrospedive study to determine the prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV) infedion in 81 Caucasian patients with confirmed hepatocellular carcinoma (HCC). Besides HBV and HCV serological markers, HCV RNA and HBV DNA were deteded in serum and liver tissue by polymerase chain readion. Overall, HCV RNA was found in 20 cases (25%), HBV DNA in 21 pa...
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metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. in cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (nafld) and non-alcoholic steatotic hepatitis (nash) the liver does not function thoroughly due to long-term damage. unfortunately the early detection of cirrhosis, hcc, na...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2015
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2015.10.420