Increased coagulation factor VIII activity in patients with familial hypercholesterolemia
نویسندگان
چکیده
منابع مشابه
Increased coagulation factor VIII activity in patients with familial hypercholesterolemia.
Acknowledgments: The authors thank Dr Reinhard Sedlmeier at Ingenium Pharmaceuticals GmbH for kindly providing them with the pSPL3b exon trapping vector and Dr Alex McMillan at Stanford University for statistical consultation. They also express gratitude to Parveen Abidi and Larry Okumoto of the Stanford Hematology Division/Cancer Institute Tissue Bank. G.P.N. was supported by National Institut...
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H EMOSTATIC DISORDERS with a varying incidence of bleeding, are common in the dysproteinemias, and are characteristic of the macroglobulinemia of \\Taldenstr#{246}m These abnormalities are most frequently attributed to abnormal platelet function,1 and depression of specific clotting factors appears to be a rare occurrence. Nilehn2 includes four instances of antihemophilic globulin ( factor VIII...
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Familial hypercholesterolemia (FH) is a disease marked by a high incidence of thrombotic episodes and hypersensitivity of the patients' platelets to naturally occurring aggregating agents. Prostaglandin/thromboxane (PG/Tx) formation, adenosine 5'-diphosphate (ADP) secretion, and fibrinogen binding to platelets are all believed to be involved in the mechanisms of platelet aggregation. Therefore,...
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ژورنال
عنوان ژورنال: Blood
سال: 2011
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-10-386227