Increase in Surgical Site Infections Caused by Gram-Negative Pathogens in Warmer Weathers Data From More Than 2 Million Surgeries

Overview of nosocomial infections caused by gram-negative bacilli.

We analyzed data from the National Nosocomial Infections Surveillance (NNIS) System from 1986-2003 to determine the epidemiology of gram-negative bacilli in intensive care units (ICUs) for the most frequent types of hospital-acquired infection: pneumonia, surgical site infection (SSI), urinary tract infection (UTI), and bloodstream infection (BSI). We analyzed >410,000 bacterial isolates associ...

Antimicrobial Resistance in Gram-negative Bacilli Isolated from Urinary Tracts Infections

Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has increased dramatically during the last 10 years, but the optimal treatment for CRGN infections is not well established due to the relative scarcity of robust clinical data. The polymyxins remain the most consistently active agents against CRGNs in vitro. Tigecycline, based on its in vitro antibacterial spectrum...

Hypophosphataemia in septicaemia: higher incidence in gram-negative than in gram-positive infections.

Phosphataemia has been investigated in 54 patients with Gram-negative septicaemias; either absolute (serum phosphate <2 mg./100 ml.) or relative (P./B.U.N. 0.04) hypophosphataemia was found in 69% of all determinations. In 37 patients with Gram-positive septicaemias hypophosphataemia was present in only 24%, many of whom had additional Gram-negative bacteriuria and possible Gram-negative septic...

Surgical site infections may be reduced by shorter duration of prophylactic antibiotic medication in urological surgeries.

In this study, we investigated whether the occurrence of surgical site infection (SSI) could be decreased by a shorter duration of prophylactic antibiotic medications. Prophylactic antibiotic selection was a 1st or 2nd generation cephalosporin or sulbactam/ampicillin for 2 days for open surgery, laparoscopic surgery, transurethral lithotripsy (TUL), and transurethral resection of the prostate (...