Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease

Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in hypertensive chronic kidney disease (CKD). In sheep with CKD NO deficiency, denervation (RDN) reduces blood pressure improves function (glomerular filtration rate). We hypothesized that this improvement glomerular rate after RDN is associated increased bioavailability. study, response to systemic inhibition NOS (NO synthase) was examined healthy at 2 30 months a sham (intact nerves) or procedure. Basal urinary total nitrate (nitrate+nitrite) excretion months, protein expression endothelial neuronal assessed months. Urinary nitrate+nitrite CKD-RDN ≈50% 70% greater than CKD-intact. During inhibition, the fall ≈20% These effects were similar those sheep. Endothelial lower CKD-intact compared CKD-RDN. summary, normalizes bioavailability restores contribution hemodynamics CKD. changes may promote improvements sustained lowering