Incorporation of Selegiline Metabolites into Hair after Oral Selegiline Intake
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Monitoring the Level of 14C-Labelled Selegiline Following Oral Administration
BACKGROUND Selegiline [(-)-deprenyl] is widely used for the treatment of Parkinson's disease in humans. OBJECTIVE Time-dependence of tissue distribution of selegiline following per os administration to rats. METHOD Oral administration of radiolabeled selegiline to rats resulted in a pattern of tissue distribution similar to that following intraperitoneal injection. Analyses were done using ...
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Nine urinary metabolites of selegiline hydrochloride [N-methyl-N-propargyl [2-phenyl-1-methyl)ethylammonium chloride], a monoamine oxidase inhibitor, after administration to humans were identified. Their identifies were confirmed by comparison of the spectra from GC/MS of peaks with those of authentic compounds. The following metabolites and unchanged drug (selegiline) were detected in urine: (...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2001
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/25.7.594