Incorporating Duplicate Genotype Data into Linear Trend Tests of Genetic Association: Methods and Cost-Effectiveness
نویسندگان
چکیده
منابع مشابه
Optimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases
The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventiona...
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ژورنال
عنوان ژورنال: Statistical Applications in Genetics and Molecular Biology
سال: 2009
ISSN: 1544-6115
DOI: 10.2202/1544-6115.1433