Incomplete Systematic Meta-analysis of Pharmacological Therapies for Opioid-Induced Constipation
نویسندگان
چکیده
منابع مشابه
Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis.
BACKGROUND There has been no definitive systematic review and meta-analysis to date examining the effect of laxatives and pharmacological therapies in chronic idiopathic constipation (CIC). OBJECTIVE To assess efficacy of these therapies systematically in CIC. DESIGN Systematic review and meta-analysis of randomised controlled trials (RCTs). DATA SOURCES MEDLINE, EMBASE, and the Cochrane ...
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OBJECTIVE Aims of this consensus panel were to determine (1) an optimal symptom-based method for assessing opioid-induced constipation in clinical practice and (2) a threshold of symptom severity to prompt consideration of prescription therapy. METHODS A multidisciplinary panel of 10 experts with extensive knowledge/experience with opioid-associated adverse events convened to discuss the lite...
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The definitions of constipation include a reference to infrequent, difficult or incomplete bowel evacuation that may lead to pain and discomfort; with stools that can range from small, hard ’rocks’, to a large bulky mass. Constipation may be debilitating among those who require chronic analgesia (7); OIC or OBD affected an average of 41 % patients taking an oral opioid for up to 8 weeks in a me...
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Chronic constipation is a common health problem that significantly affects the quality of life of patients and impacts in terms of costs; current treatments based on fiber and laxatives cause dissatisfaction to doctors and patients in more than half of the cases. New drugs are now available or in very advanced stages of research, with different and innovative mechanisms of action as prucaloprid...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 2018
ISSN: 0885-3924
DOI: 10.1016/j.jpainsymman.2018.03.003