Inactivation of yellow fever virus with amotosalen and ultraviolet A light pathogen‐reduction technology
نویسندگان
چکیده
منابع مشابه
Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination.
BACKGROUND Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted by mosquitoes. The potential for ZIKV transmission through blood transfusion was demonstrated during the ZIKV outbreak that occurred in French Polynesia from October 2013 to April 2014. Pathogen inactivation of blood products is a proactive strategy that provides the potential to reduce transfusion-transmitted dise...
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The preservation of cellular ultrastructure by glutaraldehyde is well documented (D. D. Sabatini et al., J. Cell Biol. 17:19, 1963); however, we could find no report of its inactivation of the yellow fever virus in tissue. As laboratory infection of unvaccinated personnel by this virus is also well known (G. P. Berry and S. F. Kitchen, Am. J. Trop. Med. 11:365, 1931), it is important to ascerta...
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Amotosalen and ultraviolet A (UVA) photochemical-based pathogen reduction using the Intercept™ Blood System (IBS) is an effective and established technology for platelet and plasma components, which is adopted in more than 40 countries worldwide. Several reports point towards a reduced platelet function after Amotosalen/UVA exposure. The study herein was undertaken to identify the mechanisms re...
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Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in Africa and rapidly spread into countries of the Indian Ocean basin and South-East Asia. The mean viremic blood donation risk for CHIKV on La Réunion reached 1.5% at the height of the 2005-2006 outbreaks, highlighting the need for development of safety measures to prevent transfusion-transmitted infections. We d...
متن کاملThe Ultraviolet Light and Photosensitized Inactivation of Tobacco Mosaic Virus
The quantum yield for the inactivation of tobacco mosaic virus has been determined at 253.7 mmicro and found to be 4.3 x 10(-6). The possible significance of the observed one-hit process of inactivation has been discussed in terms of the kinetics and the rupture of model substances including nucleic acid. The ultraviolet light inactivation, which proceeds independent of oxygen, occurs without c...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2020
ISSN: 0041-1132,1537-2995
DOI: 10.1111/trf.15673