منابع مشابه
Inactivation of gentamicin by penicillins in patients with renal failure.
Kinetics of gentamicin inactivation by carbenicillin and ticarcillin were studied in vitro and in 17 patients with renal failure. In vitro, the half-life of carbenicillin in human serum at 37 C is longer (19.2 +/- 0.7 h) than ticarcillin (7.2 +/- 0.6 h). Thus, incubation of gentamicin with equal concentrations of ticarcillin or carbenicillin results in greater inactivation of aminoglycoside act...
متن کاملThe Inactivation of Penicillins F, G, K, and X by Human and Rabbit Serum
1. Penicillins F, G, K, and X were all inactivated by human and rabbit serum, but two qualitatively distinct mechanisms were apparently involved. 2. One was a slow inactivation of all four penicillins by a relatively thermostable serum component which was not demonstrably affected by heating for 60 minutes at 56 degrees C. (a) In both human and rabbit serum this general inactivation of penicill...
متن کاملInactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis.
The D-alanine carboxypeptidase of Bacillus subtilis is a particulate enzyme that is irreversibly inactivated by penicillins and cephalosporins. However, the lethal concentrations of these antibiotics are not the same as those that inhibit enzymatic activity in vitro. 6-Aminopenicillanic acid inactivates at least 95% of the enzyme at nonlethal concentrations. Conversely, cephalothin is lethal at...
متن کاملBiosynthesis of penicillins; new crystalline biosynthetic penicillins.
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملAntagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins.
There are many examples of two penicillins acting synergistically, usually by one competitively inhibiting beta-lactamase, thus protecting the other from inactivation. There are few reports on penicillins antagonizing each other. Eight strains of three genera (Proteus, Escherichia, Pseudomonas) isolated at Boston City Hospital or Institut Pasteur, Paris, showed antagonism of carbenicillin or am...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 1982
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.16.5.982-984.1982