Inactivation of hepatitis B virus by intermediate-to-high-level disinfectant chemicals

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Inactivation of hepatitis B virus by intermediate-to-high-level disinfectant chemicals.

In five separate tests, hepatitis B virus in dried human plasma was exposed for 10 min at 20 degrees C to disinfectant chemicals having activity levels ranging from intermediate (e.g., 70% isopropyl alcohol) to high (e.g., 2% aqueous glutaraldehyde at pH 8.6). Five chimpanzees (one animal per disinfectant chemical) received treated material intravenously, and none showed signs of infection afte...

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Hepatitis B virus (HBV) transgenic mice whose hepatocytes replicate the virus at levels comparable to that in the infected livers of patients with chronic hepatitis have been produced, without any evidence of cytopathology. High-level viral gene expression was obtained in the liver and kidney tissues in three independent lineages. These animals were produced with a terminally redundant viral DN...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 1983

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.18.3.535-538.1983