Inactivation of Gonadotrophins

Transgenic animals and gonadotrophins.

A variety of transgenic animal models has been developed to elucidate in vivo the functions of gonadotrophin genes. Some of these have focused on regulatory aspects through expression of gonadotrophin subunit promoter-driven reporter genes. Others have been carried out by overexpression or targeted disruption of specific gonadotrophin subunit genes, or by eliminating pituitary gonadotroph cells...

Serum gonadotrophins in Down's syndrome.

Serum levels of follicle stimulating hormone (FSH) and luteinising hormone (LH) in institutionalised male patients with Down's syndrome (DS) have been found to be significantly higher than in age matched controls from the same institution. This difference is found in patients both under and over 30 years of age with respect to FSH levels, but the increase in LH levels is confined to patients wi...

Circulating levels of gonadotrophins in immature mice treated neonatally with antisera to gonadotrophins.

Urinary Excretion of Gonadotrophins with Particular Reference to Children.

Until recently there has been fairly general agreement that gonadotrophins are not detectable in the urine during childhood. Table I summarizes the results of previous investigators in this field. Of the early workers, only Catchpole and Greulich (1943) have, in serial determinations, detected gonadotrophins in young girls. More recently, studies performed on pools of urine have indicated that ...

Impact of ovarian stimulation with gonadotrophins on embryo aneuploidy.

Sir, We have read the article published in your journal by Taylor et al. (2014) with much interest. In this review the authors properly summarize the mechanisms, origins and incidence of chromosomal mosaicism in humans. The review is rigorous, exhaustive and very well-documented, and therefore we congratulate the authors for their work. Nevertheless, we find that some relevant information about...