Inability of endothelin to increase Ca2+ current in guinea-pig heart cells
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چکیده
منابع مشابه
Channel Current in Guinea Pig Detrusor Cells
The interaction of large depolarization and dihydropyridine Ca 2+ agonists, both of which are known to enhance L-type Ca 2+ channel current, was examined using a conventional whole-cell clamp technique. In guinea pig detrusor cells, only L-type Ca 2+ channels occur. A second open state (long open state: 02) of the Ca ~+ channels develops during large depolarization (at +80 mV, without Ca 2+ ago...
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This study was designed to isolate Ca2+-activated K+ current (I(KCa)) and elucidate its physiological significance in freshly isolated interstitial cells of Cajal (ICCs) of guinea-pig stomach. Single ICC was freshly isolated by enzymatically dissociating from myenteric border of gastric antrum free of circular muscles, and conventional whole-cell voltage clamp technique including immunohistoche...
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Contribution of Ca2+-influx via the slow channel to generation of the transient inward current in guinea-pig ventricular muscles was studied using a single sucrose gap voltage clamp technique. The transient inward current (TI) was induced from superfusion of the preparations with the low-K+ (0 mM), high-Ca2+ (3.6 mM) solution. Application of 2 mM-CO2+ quickly and reversibly suppressed the TI am...
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Effects ofATP on junctional conductance (gj) were investigated in paired ventricular myocytes isolated from guinea pig hearts. One cell of the pair was voltage-clamped with a single-patch pipette, and gj was measured after the perforation of the nonjunctional membrane of the partner cell. The current-voltage relation of gj was linear between -30 and +30 mV. The control gj at 5.0 mM ATP in 88 pa...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb12944.x