In vivo visualization of PARP inhibitor pharmacodynamics
نویسندگان
چکیده
منابع مشابه
In vitro analysis of PARP inhibitor nanoformulations
PARP-l is a DNA repair protein that plays a role in a number of repair pathways and also helps in transcriptional regulation; thus PARP inhibitors (PARPi), such as olaparib and BMN-673, act by inhibiting DNA damage repair. This leads to an accumulation of deleterious mutations leading to genetic instability as a result of a number of cell replications. Currently, olaparib is only available in a...
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Departments of Genetics, Pathology, Radiation Oncology, Medical Oncology and Cancer Genomics Center Netherlands, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands Departments of Toxicogenetics and Human Ge...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2021
ISSN: 2379-3708
DOI: 10.1172/jci.insight.146592