In vitro screening of blood-brain barrier penetration of clinically used acetylcholinesterase reactivators
نویسندگان
چکیده
منابع مشابه
Current in vitro and in silico models of blood-brain barrier penetration: a practical view.
Predictive, cost effective and fast evaluation of CNS penetration or unbound brain levels of NCEs, or both, presents a considerable challenge in preclinical screening in the pharmaceutical industry. It is evident that neither a single in vitro model nor a set of physicochemical parameters is capable of predicting complex in vivo measures, such as brain distribution or blood-brain barrier (BBB) ...
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Acetylcholinesterase has important role in synaptic cleft. It breaks down the acetylcholineatcholinergic synapsesand terminates the cholinergic effects. Some chemical agents likeorganophosphorus compounds (OPCs) including nerve agents and pesticides react withacetylcholinesteraseirreversibly. They inhibit normal biological enzyme action and resultin accumulation of acetylcholineand show toxic e...
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ژورنال
عنوان ژورنال: Journal of Applied Biomedicine
سال: 2010
ISSN: 1214-021X,1214-0287
DOI: 10.2478/v10136-009-0005-9