IN VITRO REVERSAL OF CHLOROQUINE RESISTANCE WITH CHLORPHENIRAMINE AGAINST AFRICAN ISOLATES OF PLASMODIUM FALCIPARUM
نویسندگان
چکیده
منابع مشابه
RESISTANCE OF PLASMODIUM FALCIPARUM TO CHLOROQUINE IN SOUTH EASTERN IRAN
In vivo and in vitro assessments of the response of P. falciparum to chloroquine using WHO standard kits and techniques were carried out in I ran Shahr, Sistan and Baluchestan province of Iran in 1985. In the in vivo assessment, 24 malaria patients treated with chloroquine (25mg/kg over three days) were followed up for one to four weeks. The mean parasite clearance time was 4.3 days and in...
متن کاملIn vitro sensitivity of southern African reference isolates of Plasmodium falciparum to chloroquine and pyrimethamine.
The in vitro sensitivity to chloroquine and pyrimethamine of 19 culture-adapted southern African reference isolates of Plasmodium falciparum was determined using a 48-hour assay. Four isolates collected in KwaZulu, Natal, were sensitive to chloroquine, and one of these was sensitive to the drug in vivo. Eight isolates from KwaZulu or Mozambique were resistant to chloroquine in vitro. Six of the...
متن کاملResistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests.
In vitro drug resistance tests of ten isolates of Plasmodium falciparum from three different collection points in Central Thailand have been carried out, and the results compared with those of similar tests with a drug-sensitive West African isolate. Judged by concentration of drug tolerated, the Thai isolates appeared to be about 10 times as resistant to chloroquine, and usually about 10(5) ti...
متن کاملIn Vitro Chloroquine Resistance in Plasmodium falciparum Isolates from Tertiary Care Hospital
Chloroquine (CQ) has been the mainstay of treatment of malaria for decades. This cost-effective and safe drug has become ineffective for treatment of falciparum malaria in many parts of the world due to development of resistance by the parasite. In addition CQ is not gametocytocidal for P. falciparum and thus cannot block transmission. The extent of problem of chloroquine resistance in P. falci...
متن کاملreversal of halofantrine resistance in plasmodium falciparum by penfluridol in vitro
penfluridol, a neuroleptic drug, considerably reversed halofantrine resistance in t9.96hf halofantrine resistant strain of plasmodium falicparum (originally chloroquine sensitive parasites), but not in k1hf halofantrine resistant strain (originally chloroquine resistant parasites)
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Science and Biology
سال: 1994
ISSN: 0021-5112,1884-2828
DOI: 10.7883/yoken1952.47.59