In vitro neoplastic transformation of hamster pineal cells by three oncogenic DNA viruses

In vitro neoplastic transformation of uveal and retinal tissue by oncogenic DNA viruses.

I Explant cultures of adult hamster retina, choroid, and iris were infected with four oncogenic DNA viruses: (1) simian virus 40 (SV40); (2) the LLE46 strain of adenovirus 7; (3) polyoma virus; and (4) human adenovirus 12. Most cultures underwent transformation as evidenced by sustained rapid growth, development of an acid pH soon after instillation of fresh media, and formation of multiple lay...

Spontaneous neoplastic transformation in vitro of mouse whole embryo cells and newborn hamster lung cells.

Three cell lines, spontaneously transformed in vitro, MWE-l and MWE-2 originating from C3Hf/Bi mouse whole embryos and NHLu-l originating from newborn syrian hamster lungs were obtained. These transformed cell lines were characterized by short generation time, marked aneuploidy in chromosome numbers and tumor induction in vivo. Histological appearance of the tumors induced by MWE-l was fibrosar...

Transformation of hamster cells in vitro by adenovirus. type 12.

Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea.

Aneuploidy is ubiquitous in cancer, and its phenotypes are inevitably dominant and abnormal. In view of these facts we recently proposed that aneuploidy is sufficient for carcinogenesis generating cancer-specific aneusomies via a chain reaction of autocatalytic aneuploidizations. According to this hypothesis a carcinogen initiates carcinogenesis via a random aneuploidy. Aneuploidy then generate...

Hormonal modification of adenovirus transformation of hamster cells in vitro.

adenovirus type 12 (Ad-12) induced foci of morphologically transformed cells in both sexes 10 to 12 days postinfection. The number of foci in replicate cultures did not vary statistically. Consistently more foci developed in female cultures than in similarly infected male cultures. Transforma tion was more efficient in pooled cultures of the same sex than in cultures grown from a single embryo....