In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis
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چکیده
منابع مشابه
In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis.
Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients...
متن کاملIn vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of ...
متن کاملMetronidazole-resistant Trichomonas vaginalis.
A 36-year-old woman with symptomatic metronidazole-resistant trichomonal vaginitis for 10 years had a total of 22 courses of treatment with either metronidazole or tinidazole according to different schedules. The minimum trichomonicidal concentration of metronidazole for the strain of Trichomonas vaginalis isolated from the patient was 160 microgram/ml compared with 1.25-10 microgram/ml for oth...
متن کاملcomparison of the effect of metronidazole, tinidazole, mango and blueberry extracts on trichomonas vaginalis in vitro
background: trichomoniasis is the most common nonviral sexually transmitted human disease that is caused by protozoan trichomonas vaginalis. metronidazole is the selective drug in trichomoniasis treatment. however, the reported cases show an increasing trend of drug resistance. this study aimed to evaluate the effect of mango and blueberry extracts on t. vaginalis. materials and methods: t. vag...
متن کاملTreatment of infections caused by metronidazole-resistant Trichomonas vaginalis.
Infections with the sexually transmitted protozoan Trichomonas vaginalis are usually treated with metronidazole, a 5-nitroimidazole drug derived from the antibiotic azomycin. Metronidazole treatment is generally efficient in eliminating T. vaginalis infection and has a low risk of serious side effects. However, studies have shown that at least 5% of clinical cases of trichomoniasis are caused b...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1996
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.40.5.1121