In Vitro Antimalarial Susceptibility of Plasmodium falciparum and Plasmodium berghei Isolates to Selected Antimalarial Agents, Column Chromatographic Subfractions of Glyphaea brevis Leaves Extract and FTIR and GCNS of SF8

Malaria still remains a life-threatening parasitic disease with universal targets set for control and elimination. This study aimed to evaluate the in vitro antimalarial susceptibility of Plasmodium falciparum isolates berghei selected agents column chromatographic subfractions Glyphaea brevis leaves extract FTIR GCMS SF8. Trager Jensen as well World Health Organisation (WHO) standardised micro-test system methods were used determine on patients’ blood samples; Column procedure was carried out obtain 11 pooled fractions; functional groups phytochemicals respectively. In anti-plasmodial activity against P. clinical had IC50 range 1.03 ?g/mL–7.63 ?g/mL while their ranges from 4.32 ?g/mL–7.89 ?g/mL. Subfraction 8 (SF8) least The spectrum showed presence isoprenoid, alcohol, phenol, alkane, alkenes, ester, carboxylic acids, aromatics nitro compounds identified dodecanoic acid, methyl ester; carotol; hexadecanoic 9-octadecenoic acid (Z)-, ester (oleic acid); stearate; heptadecanoic 16-methyl-, all reported activities. conclusion, G. has great potential drug development malaria parasite since it inhibited schizont growth possesses phytocompounds report.