In Vitro and In Silico Study of 5-[(4-Methylpiperazin-1-yl) methyl]dehydrozingerone and 5-(Morpholin-4-ylmethyl) dehydrozingerone as Lipoxygenase and Xanthine Oxidase Inhibitor

The present study was to evaluate the two aminomethyl derivatives of dehydrozingerone: 5-[(4-methylpiperazin-1-yl)methyl]dehydrozingerone and 5-(morpholin-4-ylmethyl)dehydrozingerone as lipoxygenase xanthine oxidase inhibitors. Nordihydroguaiaretic acid, allopurinol parent compound dehydrozingerone were used comparative compounds. Results indicated that 5-[(4-methylpiperazin-1-yl)methyl] 5-(morpholin-4-ylmethyl) inhibited enzyme with half-maximal inhibitory concentration 219.13 269.39 μM, respectively. Their activities comparable nordihydroguaiaretic acid a 216.84 μM. compounds also found inhibit 102.34 230.52 respectively, but their lower than 34.09 Dehydrozingerone inactive both inhibitor inhibitor. Besides, in silico carried out predict binding interaction between enzymes compared each positive controls. In conclusion, has activity they have allopurinol.