In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite

Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro . Analysis these PGSU-CNTs composites demonstrated that incorporation CNTs into a elastomer resulted enhanced mechanical strength, conductivity tailored matrix biodegradation. PGSU-CNT were subsequently formulated flexible which optimal sensitivity applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis primary neural culture confirmed exhibited low cytotoxicity, supported neuron adhesion, viability, proliferation • Functionalized network improved electrical properties polymer. A sensor from nanocomposite. nanocomposite showed strain. shown support adhesion cells. The material observed hydrolysis rate.