In utero lysis of amniotic bands

Salvage of Necrotic-Appearing Limb after In Utero Endoscopic Lysis of Constriction Bands

We report a case of amniotic band syndrome complicated by constriction bands and marked distal swelling of both lower extremities. Color Doppler interrogation of the right lower extremity revealed complete lack of blood flow below the level of the constriction. Upon fetoscopic survey, the right lower extremity beyond the constriction band appeared dusky red and discolored with desquamation, con...

Amniotic bands. A case report.

Amniotic bands in connective tissue disorders.

Amniotic bands are described in two children with Ehlers-Danlos syndrome type IV and in one with severe osteogenesis imperfecta. Since the basic defect in both of these disorders rests in collagen, which constitutes the main component of the load bearing amnion, it is proposed that these cases provide further insight into the pathogenesis of amniotic bands.

Amniotic Bands: Are They All Threat for the Fetus?

Background: Amniotic band syndrome (ABS) or amniotic band disruption is a common cause of sporadic miscellaneous fetal malformation involving limbs, trunk and the craniofacial region. Diagnosis is mainly suspected by ultrasound imaging, where the fetus is seen attached to the amniotic bands. Clinical manifestation is variable from minor constriction rings to fetal or neonatal demise secondary t...

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse

Congenital diseases account for a large portion of pediatric illness. Prenatal screening and diagnosis permit early detection of many genetic diseases. Fetal therapeutic strategies to manage disease processes in utero represent a powerful new approach for clinical care. A safe and effective fetal pharmacotherapy designed to modulate gene expression ideally would avoid direct mechanical engageme...