In-silico Molecular Docking Studies of some Isolated Phytochemicals from Biophytum veldkampii against Cyclooxygenase-II Enzyme and in vivo Anti-inflammatory Activity

Pharmacognosy Research,2021,13,4,192-198.DOI:10.5530/pres.13.4.11Published:October 2021Type:Original ArticleAuthors:Nagaraju Bandaru, D.S.N.B.K Prasanth, A.Rajasekhar Reddy, G.S.N Koteswara Rao, Kumar V.S Nemmani, and Alla Narayana Rao Author(s) affiliations:Nagaraju Bandaru1,*, D.S.N.B.K. Prasanth1, Reddy2, Rao3, Nemmani4 Rao1 1Department of Pharmacology, College Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA. 2Department Pharmaceutical Chemistry, 3Department Pharmaceutics, 4Department Shri Vishnu Bhimavaram, Abstract:Background: The current study estimate the anti-inflammatory activity whole plant Biophytum veldkampii on carageenan induced inflammation rats compiled by molecular docking studies phytocompounds from plants with Cyclooxygenase II (PDB ID: 3LN1). Methods: In this research was subjected to extraction using methanol. In-vivo assessed in-silico performed Autodock 4.0. Results: outcomes revealed that methanolic extract has most prominenant at various doses. Among all substances 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone effective rating -6.8, which is near Diclofenac, i.e. - 6.9, ensuring a strong binding fondness in between protein ligand. Conclusion: From results, conclusion can be drawn both vivo silico methods. This information sustains useful compound beneficial future clinical studies. Keywords:2, 3’, 4’-Tetrahydroxy-2 benzylcoumaranone, 6, Autodock4.0, Carageenan, II, In-silico, Inflammation, PhytochemicalView:PDF (1.66 MB)