منابع مشابه
Ofatumumab Monoclonal Antibody Affinity Maturation Through in silico Modeling
Background: Ofatumumab, an anti-CD20 mAb, was approved in 2009 for the treatment of chronic lymphocytic leukemia. This mAb acts through immune-mediated mechanisms, in particular complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity by natural killer cells as well as antibody-dependent phagocytosis by macrophages. Apoptosis induction is another mechanism of this antibody...
متن کاملMetabolic modeling of microbial strains in silico.
The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of cellular metabolic constituents, their interaction...
متن کاملIn Silico Experimental Modeling of Cancer Treatment
In silico experimental modeling of cancer involves combining findings from biological literature with computer-based models of biological systems in order to conduct investigations of hypotheses entirely in the computer laboratory. In this paper, we discuss the use of in silico modeling as a precursor to traditional clinical and laboratory research, allowing researchers to refine their experime...
متن کاملModeling the human cardiome in silico.
The past two decades have seen impressive success for reductionist biologic science, generating new experimental data at an unprecedented rate. The list of organisms with completely sequenced genomes is growing each month. In June, the completion of a draft sequence of the entire human genome was announced amid much fanfare. Molecular mechanisms for fundamental processes such as ligand-receptor...
متن کاملModeling ChIP Sequencing In Silico with Applications
ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the binding sites must be properly modeled. To develop a computational foundation to tackle these issues, we first performed a study to characterize the o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2013
ISSN: 0090-3493
DOI: 10.1097/ccm.0b013e31829a6eb4