In silico Interaction of Rhamnus’ Flavonoids With Fat Mass And Obesity Associated Protein

The anti-obesity potential of various plant extracts and their associated bioactive compounds is well known. Molecular docking studies FTO with flavonoids, using Orlistat (an drug) as a control, were performed to identify the effects Rhamnus’ flavonoids (Obesity obesity protein). Prior molecular simulation, Rhamnus flavanoids analysed AutoDockTools (version 1.5.6). Docking simulations interaction AutoDock Vina version 1.1.2. Their binding affinities obtained. BIOVIA Discovery Studio software was used visualise between receptor ligand. Our study approved ability protein, affinity Aloe Emodin Dimer>Emodin>6-Methoxysorigenin. As results, have remarkable which means they are potent molecules FTO-inhibitor. Interestingly, has lower than Aloe-emodin dimer (-8.7 vs -10.8), aloe-emodin more bound active site. In contrast, two other Rhamnnus shown when compared Orlistat.In conclution, Rhmanus phytomolecules able bind catalytic site “Orlistat” been demonstrated by docking. Thus, especially “Aloe-emodin dimer” molecule develop “anti-obesity drug”.