IN SILICO ANALYSIS OF PHYTOCHEMICALS FROM ZINGIBER OFFICINALE FOR THE INHIBITION OF TUMOR PROTEIN-53 BINDING PROTEIN 1 ASSOCIATED WITH HEPATOCELLULAR CARCINOMA

Objectives: The bioactive phytocompounds present in Zingiber officinale were assessed for their tumor-suppressing activity against TP-53 BP1 linked to hepatocellular carcinoma. Methods: study investigates the interaction of phytochemicals from Ginger (Zingiber officinale) with tumor protein TP53. Drug likeness chosen ligand was evaluated using SWISS ADME. Autodock tools used investigate interactions ligands that protein. docking visualized PLIP (Protein-Ligand Interaction Profiler). Results: It is observed all show high gastrointestinal absorption along presence blood-brain barrier permeability and have moderate solubility whereas Gingerenone A exhibits up par. Docking analysis shows high-efficiency binding (Gingerol) receptor. Conclusion: gingerol a beta-hydroxy ketone compound displays better proteins.