In Silico Analysis of HPV E6 as Drug Target with Natural Antioxidants
نویسندگان
چکیده
منابع مشابه
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response
The high-risk human papillomavirus E6 (hrHPV E6) protein has been widely studied due to its implication in cervical cancer. In response to viral threat, activated kinases phosphorylate the IRF3 autoinhibitory domain, inducing type1 interferon production. HPV circumvents the antiviral response through the possible E6 interaction with IRF3 and abrogates p53's apoptotic activity by recruiting E6-a...
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Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The life-threatening infection caused by HPV demands the need for designing anticancerous drugs. In the recent years, different compounds from natural origins, such as carrageenan, curcumin, epigallocatechin gallate, indole-3-carbinol, jaceosidin, and withaferin, have been used as a hopeful sour...
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ژورنال
عنوان ژورنال: International Journal of pharma and Bio Sciences
سال: 2020
ISSN: 0975-6299
DOI: 10.22376/ijpbs/lpr.2020.10.5.l57-64