Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil

Turpentine oil, owing to the presence of 7–50 terpenes, has analgesic, anti-inflammatory, immunomodulatory, antibacterial, anticoagulant, antioxidant, and antitumor properties, which are important for medical emulsion preparation. The addition turpentine oil squalene emulsions can increase their effectiveness, thereby reducing concentration expensive possibly deficient squalene, increasing its stability shelf life. In this study, were obtained by adding various concentrations via high-pressure homogenization, safety effectiveness studied in vitro vivo. All showed high profiles, regardless used. However, these exhibited dose-dependent effects terms both efficiency storage stability, with 1.0% had most pronounced adjuvant cytokine-stimulating activity as well indicators when stored at room temperature. Thus, it be concluded that 1% is a stable, monomodal, reliably safe ultradispersed may have pleiotropic immunopotentiating properties.