Improving Quality and Consistency in Clinical Trials via Knowledge-Based Planning, NRG Oncology RTOG 0631

Evidence Based Medicine: Clinical Trials

Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...

Improving Plan Quality in SAT-Based Planning

Improving Narrative Consistency in Planning-Based Interactive Storytelling

Interactive Storytelling (IS) systems are an emerging class of interactive entertainment applications with emphasis in narrative aspects. This paper deals with stories that have plots centered on a riddle, and describes a mechanism that can be introduced to planning-based IS in order to make the generated stories follow a specified tension arc. Results from experiments with users suggest that t...

Clinical Trials in Paediatric Oncology

Childhood and adolescent cancers are rare diseases. Despite the progress in treatment (more than two-thirds of all cases are cured), cancer remains the leading cause of death by disease in children older than 1 year. Access to new drugs that are more efficacious or better tolerated is therefore an important public health priority. The objective of our round table was thus to take inventory of t...

Serum testosterone changes in patients treated with radiation therapy alone for prostate cancer on NRG oncology RTOG 9408

Objectives We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 m...