Improved discrimination of AD patients using β-amyloid(1-42) and tau levels in CSF

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Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF.

OBJECTIVE To evaluate CSF levels of beta-amyloid(1-42) (Abeta42) alone and in combination with CSF tau for distinguishing AD from other conditions. METHODS At 10 centers in Europe and the United States, 150 CSF samples from AD patients were analyzed and compared with 100 CSF samples from healthy volunteers or patients with disorders not associated with pathologic conditions of the brain (CON)...

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Genetic discoveries in AD using CSF amyloid and tau.

The use of cerebrospinal fluid levels of Aβ42 and pTau181 as endophenotypes for genetic studies of Alzheimer's disease (AD) has led to successful identification of both rare and common AD risk variants. In addition, this approach has provided meaningful hypotheses for the biological mechanisms by which known AD risk variants modulate the disease process. In this article we discuss these success...

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Cerebrospinal Fluid β-Amyloid1–42 Levels in the Differential Diagnosis of Alzheimer’s Disease—Systematic Review and Meta-Analysis

OBJECTIVES The purpose of this study was to carry out systematic review of the literature and meta-analysis to evaluate the diagnostic utility of cerebrospinal fluid (CSF) levels of the 42 amino acid form of amyloid-beta (Aβ1-42) as a biomarker for differentiating Alzheimer's disease (AD) from non-AD dementia. METHODS Design. Systematic literature review was used to evaluate the effectiveness...

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Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss.

Alzheimer disease is characterized by extracellular beta-amyloid (Abeta) plaques and intracellular inclusions containing neurofibrillary tangles of phospho-Tau and intraneuronal Abeta associated with neuronal cell death. We generated a novel gene transfer animal model using lentiviral Abeta(1-42) that resulted in intracellular but not extracellular Abeta accumulations in the targeted rat primar...

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The aim was to quantify tau protein and â-amyloid (Aâ42) in the CSF of patients with sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer’s disease (AD), and controls. Double sandwich enzyme linked immunosorbent assays (ELISAs) were used for measurments. Tau was increased 58-fold in CJD and 3.5-fold in AD compared with controls, whereas Aâ42 was decreased 0.5-fold in both CJD and AD. A cut oV le...

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ژورنال

عنوان ژورنال: Neurology

سال: 1999

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.52.8.1555