Improved Bioavailability of Poorly Water-Soluble Drug Curcumin in Cellulose Acetate Solid Dispersion

Solubility Enhancement of Poorly Water Soluble Drugs by Solid Dispersion

Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

BACKGROUND Indirubin, isolated from the leaves of the Chinese herb Isatis tinctoria L, is a protein kinase inhibitor and promising antitumor agent. However, the poor water solubility of indirubin has limited its application. In this study, a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) was developed to improve the oral bioavailability of indirubin. METHODS A prototyp...

Studies on dissolution enhancement of prednisolone, a poorly water-soluble drug by solid dispersion technique.

INTRODUCTION Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. METHODS Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose a...

Solid Dispersion - a Novel Approach for Enhancement of Bioavailability of Poorly Soluble Drugs in Oral Drug Delivery System

It has been estimated that nearly 35-40 % of drugs suffer from poor aqueous solubility and it affects the absorption of drug from gastrointestinal tract that leads to high inter and intra subject variability, poor oral bioavailability, increase in dose, reduction in therapeutic efficiency and finally failure in formulation development. Various formulation strategies like micronization, solubili...

Solid Dispersions: An Overview To Modify Bioavailability Of Poorly Water Soluble Drugs