Improved adenoviral vectors: cautious optimism for gene therapy
نویسندگان
چکیده
منابع مشابه
Gene therapy for cardiovascular disease: a case for cautious optimism.
There is currently intense interest in the development of gene therapy for cardiovascular disease. The stimulation of therapeutic angiogenesis for ischemic heart disease has been one of the areas of greatest promise. Encouraging results have been obtained with the angiogenic cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor in animal models, leading to clini...
متن کاملAdenoviral Vectors for Hemophilia Gene Therapy
Hemophilia is an inherited blood clotting disorder resulting from deficiency of blood coagulation factors. Current standard of care for hemophilia patients is frequent intravenous infusions of the missing coagulation factor. Gene therapy for hemophilia involves the introduction of a normal copy of the deficient coagulation factor gene thereby potentially offering a definitive cure for the bleed...
متن کاملReasons for Cautious Optimism
Luis G. Melo, Alok S. Pachori, Deling Kong, Massimiliano Gnecchi, Kai Wang, Richard E. Myocardium : Reasons for Cautious Optimism Molecular and Cell-Based Therapies for Protection, Rescue, and Repair of Ischemic Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Aven...
متن کاملTargeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas.
STUDY QUESTION Is targeted adenovirus vector, Ad-SSTR-RGD-TK (Adenovirus -human somatostatin receptor subtype 2- arginine, glycine and aspartate-thymidine kinase), given in combination with ganciclovir (GCV) against immortalized human leiomyoma cells (HuLM) a potential therapy for uterine fibroids? SUMMARY ANSWER Ad-SSTR-RGD-TK/GCV, a targeted adenovirus, effectively reduces cell growth in Hu...
متن کاملRenal radiosurgery: cautious optimism.
PONSKY LE. Renal radiosurgery: cautious optimism. Can J Urol 2013;20(5):6950. evaluation after treatment also needs to be assessed. We need to ensure radiographic response matches that of pathologic response. Our group agrees with the authors that radiosurgery with technologies such as the CyberKnife and others, may potentially offer such advantages. Although the current technique requires the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: QJM
سال: 1997
ISSN: 1460-2393
DOI: 10.1093/qjmed/90.2.105