Impracticalities of thiopurine S-methyltransferase determination in daily inflammatory bowel disease practice
نویسندگان
چکیده
منابع مشابه
Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease
BACKGROUND Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of pediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to examine the sensitivity and specificity of TPMT genotyping for TPMT...
متن کاملAnalysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.
BACKGROUND AND AIMS Myelosuppression observed in patients with inflammatory bowel disease (IBD) treated with azathioprine (AZA) has been attributed to low thiopurine S-methyltransferase (TPMT) activity. TPMT activity is dependent on the genetic polymorphism of high-versus low-metabolizing alleles. We investigated the association between TPMT genotypes and myelosuppression in Japanese IBD patien...
متن کاملDosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel disease patients.
With great interest we read the article by Kaskas et al (Gut 2003;52:140–2) about safe treatment of thiopurine S-methyltransferase (TPMT) deficient Crohn’s disease patients with azathioprine (AZA). In this paper it is illustrated that TPMT-deficient patients can be successfully treated with very low doses of AZA (,10% of standard initial dose). Unfortunately, this is not the case for all homozy...
متن کاملAn Epidemiological Study of Thiopurine-methyltransferase Variants in a Croatian Inflammatory Bowel Disease Patient Cohort.
Thiopurine S-methyltransferase (TPMT) is an enzyme that converts thiopurine drugs into inactive metabolites. Over 20 variant TPMT-encoding alleles, which cause reduced enzymatic activity, have been discovered so far. Our aim was to investigate the frequencies of variant alleles, i.e. genotypes in inflammatory bowel disease (IBD) patients and healthy individuals and to compare these frequencies ...
متن کاملMeasurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.
BACKGROUND Measurement of 6-thioguanine nucleotide concentrations may be useful for optimising treatment with azathioprine and 6-mercaptopurine. METHODS We conducted a study of 170 patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine to determine the relationship between 6-thioguanine nucleotide concentrations and both disease activity, as measured by the inf...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology and Therapeutics
سال: 2006
ISSN: 0269-2813,1365-2036
DOI: 10.1111/j.1365-2036.2006.02831.x