Imported drug-resistant severe malaria

Imported Tertian Malaria Resistant to Primaquine

In Plasmodium vivax and Plasmodium ovale malaria, some of the liver stage parasites remain dormant. The activation of these dormant forms (called hypnozoite) can give rise to relapse weeks, months or years after the initial infection. To prevent relapses, a course of primaquine may be given as terminal prophylaxis to patients. Different strains of Plasmodium vivax vary in their sensitivity to p...

Imported quinine resistant Plasmodium falciparum malaria in Sri Lanka.

New emerging drug-resistant malaria

CLINICAL QUESTION What is the best treatment for artemisinin-resistant malaria? RESULTS There is still no better treatment than the presently used artemisinin-based combination therapies. A new antimalarial drug for this problem needs to be found. IMPLEMENTATION Pitfalls to avoid when treating drug-resistant malaria:

Severe Imported Plasmodium falciparum Malaria, France, 1996–2003

Little is known about severe imported Plasmodium falciparum malaria in industrialized countries where the disease is not endemic because most studies have been case reports or have included <200 patients. To identify factors independently associated with the severity of P. falciparum, we conducted a retrospective study using surveillance data obtained from 21,888 P. falciparum patients in Franc...

Challenges of drug-resistant malaria

Over the past six decades, the drug resistance of Plasmodium falciparum has become an issue of utmost concern. Despite the remarkable progress that has been made in recent years in reducing the mortality rate to about 30% with the scaling-up of vector control, introduction of artemisinin-based combination therapies and other malaria control strategies, the confirmation of artemisinin resistance...