Implementing a Geriatric Assessment in Cooperative Group Clinical Cancer Trials: CALGB 360401

Development of clinical trials in a cooperative group setting: the eastern cooperative oncology group.

PURPOSE We examine the processes and document the calendar time required to activate phase II and III clinical trials by an oncology group: the Eastern Cooperative Oncology Group (ECOG). METHODS Setup steps were documented by (a) interviewing ECOG headquarters and statistical center staff, and committee chairs, (b) reviewing standard operating procedure manuals, and (c) inspecting study recor...

Cooperative Clinical Trials in Cancer – the need for increased capacity

Acknowledgements Sincere thanks are offered to the many people who have given up their time to contribute to this report by participation in interviews, providing comments on the drafts, participation in the workshop and in assisting in many other ways. The contributions of so many busy people has been of inestimable value and is greatly appreciated. The fact that it has not been possible to re...

The role of cooperative groups in cancer clinical trials.

New generation of breast cancer clinical trials implementing molecular profiling

The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. Thi...

Radiotherapy protocol deviations and clinical outcomes: a meta-analysis of cooperative group clinical trials.

BACKGROUND Noncompliance with radiotherapy (RT) protocol guidelines has been linked to inferior clinical outcomes. We performed a meta-analysis of cooperative group trials to examine the association between RT quality assurance (QA) deviations and disease control and overall survival (OS). METHODS We searched MEDLINE and the Cochrane Central Register of Controlled Trials for multi-institution...