Impaired posterior cingulate cortex–parahippocampus connectivity is associated with episodic memory retrieval problems in amnestic mild cognitive impairment

Episodic memory retention and retrieval decline are the most common impairments observed in amnestic mild cognitive impairment (aMCI) patients who progress to Alzheimer's disease (AD). Clinical electroencephalography research shows that with dementia due AD exhibit a slowing of neural electrical activity parietal cortex. Memory has further suggested successful performance is associated changes posterior cingulate–parahippocampal cortical network together increased θ–γ oscillatory coupling, where θ oscillations act as carrier waves for γ oscillations, which contain actual information. However, neurophysiological link between clinical studies investigating aMCI lacking. In this study, we look at brain how it relates performance. We demonstrate decreased power cingulate cortex left right parahippocampus comparison control participants. This goes reduced coherence altered addition, comparing participants reveals an effect coupling cortex, parahippocampus. Taken together, our results show interact via recollection patients, offering potential candidate mechanism aMCI.