Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice.
نویسندگان
چکیده
منابع مشابه
Corticotropin-releasing hormone physiology
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
متن کاملCorticotropin-releasing hormone receptors.
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural...
متن کاملResponse to corticotropin-releasing hormone infusion in cocaine-dependent individuals.
CONTEXT Corticotropin-releasing hormone (CRH), through the hypothalamic pituitary adrenal axis and other brain stress systems, is involved in the emotional dysregulation associated with cocaine dependence. Little is known about the response of cocaine-dependent individuals to CRH administration. OBJECTIVE The primary objective was to examine the hypothalamic-pituitary-adrenal axis and the sub...
متن کاملRegulation of adrenocorticotropic hormone secretion: lessons from mice deficient in corticotropin-releasing hormone.
words of Hans Selye from the 1940s still ring true today. Selye recognized that physical, emotional, and environmental challenges (stressors) elicit a variety of physiological responses and that our ability to respond and adapt to these stressors is critical to our survival. In the 50 years since these initial observations, we have learned a great deal about the complex system that allows us to...
متن کاملCorticotropin-releasing hormone in nonhuman primates.
Understanding the many roles that corticotropin-releasing hormone (CRH) plays in facilitating the ordinary and extraordinary events that an individual faces during a lifetime is a complex task, and yet this knowledge is fundamental to understanding our own behaviour and physiology. During the past 25 years, the study of CRH in nonhuman primates, our closest genetic relatives, has grown rapidly....
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119487