Impaired bone microarchitecture and strength in patients with tumor?induced osteomalacia

Some studies based on bone biopsy have demonstrated that in patients with tumor-induced osteomalacia (TIO) the mineralization process of matrix is profoundly disturbed. However, interrelationship between clinical and biochemical features microarchitecture this disease needs further analysis. With purpose mind, we set out three objectives: (i) to determine estimated strength a group using high-resolution peripheral quantitative computed tomography (HR-pQCT) finite element analysis (FEA), (ii) investigate correlations duration disease, features, density, HR-pQCT FEA parameters, (iii) compare parameters healthy control group. Ten TIO were included. All had non-resolved disease. At distal radius, all significantly affected comparison controls. tibia, impaired, except for trabecular thickness. more tibia than radius. Women (n = 7) lower In men 3), at tibia. Alkaline phosphatase levels exhibited negative correlation failure load, stiffness. Higher parathyroid hormone correlated poorer parameters. We believe TIO, hormonal disturbances lack mechanical stimulus specially converge generate an extremely harmful combination health. © 2021 American Society Bone Mineral Research (ASBMR).