Impact of stressful life events in mood disorders

Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.

It is well established that stress is a risk factor for onset of mood disorders. Emerging evidence suggests that genetic vulnerability may also moderate individual responsiveness to stress. The most compelling evidence regards the polymorphism within the promoter region of the serotonin transporter gene (SERTPR), which has been reported to moderate the risk for depression, in conjunction with l...

Childhood Stressful Life Events and Bipolar Spectrum Disorders

In a cross–sectional study, we investigated the association of reported childhood stressful life events and bipolar spectrum disorders in an undergraduate sample. Specifically, we tested the harsh environment and stress generation explanations of the childhood stress and bipolar disorder relationship. The final sample included 155 bipolar spectrum participants and 155 demographically matched no...

Presumptive Stressful Life Events Scale (psles) — a New Stressful Life Events Scale for Use in India

Using an open ended question along with Holme's and Rahe's Social Readjustment Rating Schedule on a sample of two hundred adult subjects, a suitable scale of stressful life events experienced by the Indian population was constructed and standardized for two time spaces, that is, last one year and life time. Analysis of various demographic variables for this population revealed no differences on...

Role of Stressful Life Events in Mania

The study investigated the role of stressful life events and family pathology in manic illness-selecting 30 cases of mania from Psychiatric Centre Jaipur and 30 normal controls from paramedical staff of psychiatric hospital. Both manics and normals were matched in terms of age, sex, education, marital status etc. All the subjects were subjected to Paykel's life events questionnaire, and an inte...

The Role of Stressful Life Events