Impact of Quorum Sensing System on Virulence Factors Production in Pseudomonas aeruginosa
نویسندگان
چکیده
Pseudomonas aeruginosa is an important pathogen that frequently associated with nosocomial infections. The goal of this work was to determine the relationship between quorum sensing system (QS) and production virulence factors in P. aeruginosa. A number 100 isolates were collected from various clinical sources different Mansoura university hospitals period April 2018 till 2019. PCR screening QS genes carried out including lasI, lasR, rhlI rhlR. Thereafter, assay established biofilm formation, pyocyanin production, protease lipase hemolysin as well swimming motility. Finally, statistical analysis data performed confirm factors. Out isolates, 27 deficient. revealed 8 lacked lasR gene, 15 rhlR genes, 1 isolate lasI 2 rhlR, genes. There a significant decrease observed pyocyanin, protease, lipase, formation motility deficient comparison non-QS ones. clear association This could open door for novel promising targets developing new therapeutic strategies against infections caused by pathogen.
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ژورنال
عنوان ژورنال: Journal of Pure and Applied Microbiology
سال: 2022
ISSN: ['2581-690X', '0973-7510']
DOI: https://doi.org/10.22207/jpam.16.2.51