Impact of protein D-containing pneumococcal conjugate vaccines on non-typeable Haemophilus influenzae acute otitis media and carriage
نویسندگان
چکیده
منابع مشابه
Efficacy of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine against acute otitis media and nasopharyngeal carriage in Panamanian children – A randomized controlled trial
We previously reported 10-valent pneumococcal non-typeable Haemophilus influenzae (NTHi) protein D conjugate vaccine (PHiD-CV) efficacy in a double-blind randomized trial (ClinicalTrials.gov: NCT00466947) against various diseases, including acute otitis media (AOM). Here, we provide further analyses. In the Panamanian subset, 7,359 children were randomized (1:1) to receive PHiD-CV or control va...
متن کاملPneumococcal Conjugate Vaccines and Otitis Media
1Global Vaccine Development, GlaxoSmithKline Vaccines, 1300 Wavre, Belgium 2Department of Pathophysiology and Transplantation, University of Milan and Fondazione IRCCS Cà, Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy 3Paediatric Infectious Diseases, Infection Control and Epidemiology Unit, Université Libre de Bruxelles, 1020 Brussels, Belgium 4Multi-Centre Otitis Media Study Group, ...
متن کاملTranscriptome signature in young children with acute otitis media due to non-typeable Haemophilus influenzae.
Non-typeable Haemophilus influenzae (NTHi) causes acute otitis media (AOM) in young children. In our recent paper in Microbes and Infection we described the transcriptome signature elicited from PBMCs at onset of AOM caused by Streptococcus pneumoniae. In the current study we found very different results with NTHi AOM infections; 5.1% of 29 187 genes were differentially regulated by more...
متن کاملReduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine
BACKGROUND In October 2009, 7-valent pneumococcal conjugate vaccine (PCV7: Prevenar(TM) Pfizer) was replaced in the Northern Territory childhood vaccination schedule by 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10; Synflorix(™) GlaxoSmithKline Vaccines). This analysis aims to determine whether the reduced prevalence of suppurative otitis media measured in...
متن کاملConjugate vaccines and the carriage of Haemophilus influenzae type b.
Pharyngeal carriage of Haemophilus influenzae type b (Hib) is important in the transmission of Hib organisms, the pathogenesis of Hib disease, and the development of immunity to the bacterium. The remarkable success of current vaccination programs against Hib has been due in part to the effect of conjugate Hib vaccines in decreasing carriage of Hib. This review explores evidence for this effect...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2017
ISSN: 1476-0584,1744-8395
DOI: 10.1080/14760584.2017.1333905