Impact of orally-administered oligosaccharides in a murine model of food allergy

Food allergy is a refractory condition for which there are no standard effective therapies. Prebiotic supplementation such as oligosaccharides in infants was found to be associated with decreased risk of allergic diseases. Raffinose and stachyose the major identified beans; these have properties regulating homeostasis. In this study, we explored use means prevent food using an ovalbumin (OVA) sensitization challenge model reductions body temperature diarrhea were evaluated. administered ad libitum drinking water five weeks from one week prior first through final oral administration OVA. Among our findings, treatment suppressed prevented elevations OVA-specific immunoglobulin (Ig)G1. We hypothesize that suppression responses actions regulatory T cells promoted by utilization intestinal microbiota. Taken together, findings suggest daily ingestion might prevention allergy.