Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques

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Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques.

In this study we examined the effects of non-myeloablative total body irradiation (TBI) in combination with immunosuppressive chemotherapy on immune homeostasis in rhesus macaques. Our results show that the administration of cyclosporin A or tacrolimus without radiotherapy did not result in lymphopenia. The addition of TBI to the regimen resulted in lymphopenia as well as alterations in the mem...

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ژورنال

عنوان ژورنال: Clinical & Experimental Immunology

سال: 2015

ISSN: 0009-9104

DOI: 10.1111/cei.12646