Impact of Hepatic Iron Overload in the Evaluation of Steatosis and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease Using Vibration-Controlled Transient Elastography (VCTE) and MR Imaging Techniques: A Clinical Study

Three main non-invasive imaging methods are routinely used for the assessment of liver fibrosis and steatosis in patients with nonalcoholic fatty disease (NAFLD): vibration-controlled transient elastography (VCTE) using FibroScan device, magnetic resonance (MRI) based on proton density fat fraction (PDFF), (MRE). The purpose our study is to evaluate efficiency VCTE findings compared two others methods, analyze impact hepatic iron overload these comparisons. A clinical was performed 94 NAFLD radiology department ACRIM-Polyclinic Saint-Côme (France). also included 17 hemochromatosis, measured from T2⁎ MRI. tissues all were evaluated 1) (including controlled attenuation (CAP) stiffness parameters), 2) MRI (fat parameter), 3) MRE (stiffness parameter) techniques. performance assessed by estimating area under ROC curve (AUC) without or hemochromatosis. Spearman's correlation comparison measurements MRE. VCTE-based CAP significantly correlated PDFF (P<0.01) subgroup correlations failed not those MR VCTE, modalities don't give concordant results