Impact of cerebellar beta entrainment using non-invasive brain stimulation: Insights from an ongoing rhythmic TMS—EEG study in healthy human participants

Abstract Oscillations play a pivotal role in shaping cerebellar local activity and its communication with neocortical areas involved learning motor skills. Previous studies have emphasized the presence potentially important of beta (15-30 Hz) oscillations such processes. Yet, distribution causal nature interregional synchronization patterns at frequencies remain elusive. The present study aims to better understand functional mechanisms by which cerebellum synchronizes widespread cortical regions. This will pave way identify modulate specific electrophysiological properties these networks. To this end, we sought entrain frequency transcranial magnetic stimulation (TMS) characterize cerebello-cortical sensory-motor A cohort 20 healthy adult participants received trial-by-trial blocks 4-pulses bursts either rhythmic (20 Hz, experimental condition) or arrhythmic (control TMS delivered over right cerebellum, while EEG was also recorded. occipital/parietal site performed separate served assess specificity stimulation. After cleaning pre-processing, computed averaged power inter-trial coherence signals elicited frontal, central parietal areas. Current interim analyses support tolerability feasibility TMS—EEG recordings, our ability signs beta-induced entrainment ruling out unspecific effects (artifacts triggered clicking-sound, scalp-tapping, etc). is first overcoming limitations ‘offline’ repetitive approaches assessing effective connectivity between cerebral systems using approaches. outcome neurophysiological based on frequency-specific mechanisms, would ultimately influence Research Category Technology Methods Basic Research: 10. Transcranial Magnetic Stimulation Keywords: Cerebellum, Oscillations, Entrainment, TMS-EEG