Impact of blood collection method on first-trimester dried blood free Beta hCG and PAPP-A
نویسندگان
چکیده
منابع مشابه
Maternal serum free beta-hCG and PAPP-A in fetal sex chromosome defects in the first trimester.
We have studied maternal serum free beta-hCG and PAPP-A, and fetal nuchal translucency (NT) in a series of 46 cases of fetal Turner's syndrome, 13 cases of other sex chromosomal anomalies and compared these with 947 control pregnancies in the first trimester. In cases of Turner's syndrome (45,X) the median fetal NT was significantly higher than in controls (4.76 MoM), the median PAPP-A was sign...
متن کاملThe impact of fetal gender on first trimester nuchal translucency and maternal serum free beta-hCG and PAPP-A MoM in normal and trisomy 21 pregnancies.
OBJECTIVE To investigate if fetal sex has an impact on 1st trimester combined screening for aenuploidy. METHODS We studied the first trimester PAPP-A, free beta-human chorionic gonadatropin (beta-hCG) and nuchal translucency levels in 56,024 normal, singleton pregnancies with known fetal sex at birth. We also examined the distributions in 722 pregnancies with trisomy 21 of known fetal sex. ...
متن کاملPrediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler.
BACKGROUND Previous studies have shown an association between low first trimester maternal serum free beta-hCG and PAPP-A and subsequent development of pregnancy complications. Similarly, uterine artery Doppler in the late second trimester has shown that high impedance to flow is associated with increased risk for preeclampsia and fetal growth restriction. The objective of this study is to dete...
متن کاملIncorporation of dried blood alpha fetoprotein into traditional first trimester Down syndrome screening service
OBJECTIVE The aim of this study was to determine whether incorporation of dried blood alpha fetoprotein (AFP) into first trimester screening using the biochemical markers free Beta human chorionic gonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) can improve screening performance. METHODS A retrospective study of 34 Down syndrome and 1185 unaffected dried blood specimens. ...
متن کاملFirst trimester prenatal diagnosis of trisomy 21 in discordant twins using fetal nuchal translucency thickness and maternal serum free beta-hCG and PAPP-A.
Screening for trisomy 21 in twin pregnancies poses a serious clinical, ethical and moral dilemma (Reynolds, 1995), leading some authors to advocate that such screening should be discouraged (Wald et al., 1997). Nevertheless, algorithms have been developed (Wald et al., 1991; Spencer et al., 1994) for biochemical screening in twins during the second trimester which will allow detection of approx...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2013
ISSN: 0004-5632,1758-1001
DOI: 10.1177/0004563213484906