IMP3 signatures of fallopian tube: a risk for pelvic serous cancers
نویسندگان
چکیده
منابع مشابه
IMP3 signatures of fallopian tube: a risk for pelvic serous cancers
BACKGROUND Recent advances suggest fallopian tube as the main cellular source for women's pelvic serous carcinoma (PSC). In addition to TP53 mutations, many other genetic changes are involved in pelvic serous carcinogenesis. IMP3 is an oncofetal protein which has recently been observed to be overexpressed in benign-looking tubal epithelia. Such findings prompted us to examine the relationship b...
متن کاملThe distal fallopian tube: a new model for pelvic serous carcinogenesis.
PURPOSE OF REVIEW Research over the past 50 years has yielded little concrete information on the source of pelvic serous cancer in women, creating a knowledge gap that has adversely influenced our ability to identify, remove or prevent the earliest stages of the most lethal form of ovarian cancer. RECENT FINDINGS The distal fallopian tube is emerging as an established source of many early ser...
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Copyright: © 2012 Zheng W et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In 2012, it is estimated that 22,280 new cases of ovarian carcinoma will be diagnosed in the United States, with 15500 associate...
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The fimbria is the most common site of early serous cancer (tubal intraepithelial carcinoma or STIC) in women with BRCA mutations (BRCA+). A candidate serous cancer precursor--the p53 signature--has been found in nonneoplastic secretory cells of the fimbria, suggesting serous carcinogenesis in the tube (SCAT). This study surveyed fallopian tubes from 3 populations to characterize the morphologi...
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ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2014
ISSN: 1756-8722
DOI: 10.1186/s13045-014-0049-5