IMP3 as a cytoplasmic biomarker for early serous tubal carcinogenesis
نویسندگان
چکیده
منابع مشابه
IMP3 as a cytoplasmic biomarker for early serous tubal carcinogenesis
BACKGROUND Serous tubal intraepithelial carcinoma (STIC) and the p53 signature in tubal mucosa have been supported to be precursor lesions in high-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneum. It remains critical to find biomarkers for precursor lesions in order to detect HGSCs efficiently. IMP3 is an oncoprotein that has been explored in human malignancies. No stu...
متن کاملOvarian serous carcinogenesis from tubal secretory cells.
Due to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both...
متن کاملIMP3 signatures of fallopian tube: a risk for pelvic serous cancers
BACKGROUND Recent advances suggest fallopian tube as the main cellular source for women's pelvic serous carcinoma (PSC). In addition to TP53 mutations, many other genetic changes are involved in pelvic serous carcinogenesis. IMP3 is an oncofetal protein which has recently been observed to be overexpressed in benign-looking tubal epithelia. Such findings prompted us to examine the relationship b...
متن کاملAdvances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis.
Early serous carcinoma in fallopian tube or serous tubal intraepithelial carcinoma (STIC), an early lesion limited to the epithelium of the fallopian tube and firstly identified from specimen obtained by prophylactic salpingo-oophorectomy, has provided insight into pelvic high grade serous carcinoma (HGSC). Increasing evidence indicates that STIC is a likely precursor for HGSC and several studi...
متن کاملFallopian tube secretory cell expansion: a sensitive biomarker for ovarian serous carcinogenesis [Retraction].
[This retracts the article on p. 230 in vol. 8, PMID: 27069556.].
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2014
ISSN: 1756-9966
DOI: 10.1186/s13046-014-0060-2