IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way

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Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice.

In this report, we have investigated the relationship between androgen levels and prostate tumorigenesis in Nkx3.1; Pten mutant mice, a genetically engineered mouse model of human prostate cancer. By experimentally manipulating serum levels of testosterone in these mice for an extended period (i.e., 7 months), we have found that prolonged exposure of Nkx3.1; Pten mutant mice to androgen levels ...

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Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN

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Analysis of IMP3 expression in prostate adenocarcinomas.

OBJECTIVE Prostate cancer is the second most common cause of male cancer deaths after lung cancer in developed countries. The prognostic factors currently identified for prostate carcinoma include preoperative serum PSA, TNM staging system, histological grade and surgical margin status and are composed of the clinically most important and useful parameters. However, all the markers studied have...

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Pten Dose Dictates Cancer Progression in the Prostate

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PTEN dose variations on cancer progression, we have generated by homologous recombination a hypomorphic Pten mouse mutant series with decreasing Pten...

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Role of PTEN gene in progression of prostate cancer.

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ژورنال

عنوان ژورنال: Journal of Experimental & Clinical Cancer Research

سال: 2020

ISSN: 1756-9966

DOI: 10.1186/s13046-020-01657-0