IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype
نویسندگان
چکیده
منابع مشابه
Mutations acquired by hepatocellular carcinoma recurrence give rise to an aggressive phenotype
Recurrence of hepatocellular carcinoma (HCC) even after curative resection causes dismal outcomes of patients. Here, to delineate the driver events of genomic and transcription alteration during HCC recurrence, we performed RNA-Seq profiling of the paired primary and recurrent tumors from two patients with intrahepatic HCC. By comparing the mutational and transcriptomic profiles, we identified ...
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Background: Kinesin spindle protein (KSP) plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA (siRNA) in Hep3B cells and evaluate its anti-tumor activity. Methods: Three siRNA targeting KSP (KSP-siRNA #1-3) and one mismatched-siRNA (...
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Kol Jia Yong, B.Sc., Chong Gao, M.D., Ph.D., Joline S.J. Lim, M.B., B.S., Benedict Yan, M.B., B.S., Henry Yang, Ph.D., Todor Dimitrov, Ph.D., Akira Kawasaki, M.D., Ph.D., Chee Wee Ong, M.Sc., Kwong-Fai Wong, Ph.D., Sanghoon Lee, Ph.D., Sharada Ravikumar, M.D., Ph.D., Supriya Srivastava, M.D., Xi Tian, B.S., Ronnie T. Poon, M.B., B.S., Ph.D., Sheung Tat Fan, M.D., D.Sc., John M. Luk, D.Med.Sc., ...
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BACKGROUND Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. In the heterogeneous group of hepatocellular carcinomas, those with characteristics of embryonic stem-cell and progenitor-cell gene expression are associated with the worst prognosis. The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is asso...
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Microsatellite instability (MSI) seems to be a rare event in hepatocarcinogenesis and might actually be associated with the progression of hepatocellular carcinoma (HCC) in which the liver is often the site of chronic hepatitis or cirrhosis. The aim of this work was to define the MSI phenotype in HCC affecting exclusively normal livers to avoid slippage errors due to cirrhosis. One hundred and ...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2015
ISSN: 2041-4889
DOI: 10.1038/cddis.2015.241